Issue 5, 2023
From the journal:

Organic Chemistry Frontiers

Photocatalyzed alkoxycarbonylmethylation of pyridines with α-diazoacetates†

Haisheng Xie,a   Zhongfeng Luo,a   Fengjuan Chen,*a   Huanfeng Jiang ORCID logo a  and  Wei Zeng ORCID logo *a  

* Corresponding authors

a Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China
E-mail: zengwei@scut.edu.cn, cfj5126@scut.edu.cn

Abstract

A photocatalyzed regioselective alkoxycarbonylmethylation of 2-aminopyridines with α-diazoacetates has been developed. This method provides a metal-free strategy to assemble 2-aryl-2-pyridylacetic esters via a direct pyridyl Csp2–H bond carbenoid insertion under mild conditions.

Graphical abstract: Photocatalyzed alkoxycarbonylmethylation of pyridines with α-diazoacetates

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Article information

DOI
https://doi.org/10.1039/D2QO01818G
Article type
Research Article
Submitted
15 Nov 2022
Accepted
20 Jan 2023
First published
24 Jan 2023

Org. Chem. Front., 2023,10, 1270-1274

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Photocatalyzed alkoxycarbonylmethylation of pyridines with α-diazoacetates

H. Xie, Z. Luo, F. Chen, H. Jiang and W. Zeng, Org. Chem. Front., 2023, 10, 1270 DOI: 10.1039/D2QO01818G

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