Issue 7, 2023

Radical addition/spirocyclization cascade of tryptamine-derived isocyanides with aryl boronic acids: efficient access to spiroindoline derivatives

Abstract

An efficient Mn(III)-promoted cascade reaction of tryptamine-derived isocyanides with arylboronic acids for accessing spiroindoline derivatives is described. The reaction proceeds via a radical addition/spirocyclization pathway, providing spiroindolines in good yields under mild conditions.

Graphical abstract: Radical addition/spirocyclization cascade of tryptamine-derived isocyanides with aryl boronic acids: efficient access to spiroindoline derivatives

Supplementary files

Article information

Article type
Research Article
Submitted
16 Dec 2022
Accepted
19 Feb 2023
First published
21 Feb 2023

Org. Chem. Front., 2023,10, 1660-1668

Radical addition/spirocyclization cascade of tryptamine-derived isocyanides with aryl boronic acids: efficient access to spiroindoline derivatives

S. Jiang, Y. Huang, X. Wang, X. Xu and S. Ji, Org. Chem. Front., 2023, 10, 1660 DOI: 10.1039/D2QO01992B

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