Enantioselective total syntheses of (−)-cephalotaxine and (−)-amathaspiramide F through a key Ir/Cu dual catalysis

Abstract

A recently developed Ir/Cu dual catalysed allylation, which could efficiently provide excellent enantio- and diastereoselectivity in the construction of vicinal tertiary and N-substituted quaternary stereogenic centres in one step, is strategically utilised for the first time in the syntheses of two alkaloids—cephalotaxine and amathaspiramide F.