Issue 13, 2023

Direct access to β-arylketoesters by NHC/photoredox catalyzed alkoxycarbonylation–carbonylation of styrenes

Abstract

We report herein a dicarbonylation of styrenes with aryl fluorides and potassium 2-ethoxy-2-oxoacetate by cooperative NHC and photoredox catalysis with good functional group tolerance and moderate to high yields. This gentle and efficient approach offers a valuable alternative to known strategies for the synthesis of β-arylketoesters. Mechanistic studies have shown that this protocol proceeds via a radical-addition/coupling/elimination cascade reaction.

Graphical abstract: Direct access to β-arylketoesters by NHC/photoredox catalyzed alkoxycarbonylation–carbonylation of styrenes

Supplementary files

Article information

Article type
Research Article
Submitted
07 Apr 2023
Accepted
28 May 2023
First published
29 May 2023

Org. Chem. Front., 2023,10, 3288-3292

Direct access to β-arylketoesters by NHC/photoredox catalyzed alkoxycarbonylation–carbonylation of styrenes

Y. Liu, Z. Wu, W. Li, M. Zhang, Y. Zhang, S. Deng, S. Fan, Y. Zhu and Y. Feng, Org. Chem. Front., 2023, 10, 3288 DOI: 10.1039/D3QO00515A

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