Issue 12, 2023

Cross-coupling of aldehydes and α-bromophosphonates to modularly access α-substituted-β-ketophosphonates under dual nickel/photoredox catalysis

Abstract

β-Ketophosphonates are extremely valuable molecules in organic synthesis. Compared with the numerous synthetic methods for their simple skeletons, the routes for accessing α-substituted-β-ketophosphonates usually need multiple steps with strong bases or harsh conditions. Herein, a modular and direct protocol is reported for these types of compounds by utilizing the easily available aldehydes and α-bromophosphonates via dual nickel/photoredox catalysis. Some special β-keto frameworks were also successfully obtained with this strategy.

Graphical abstract: Cross-coupling of aldehydes and α-bromophosphonates to modularly access α-substituted-β-ketophosphonates under dual nickel/photoredox catalysis

Supplementary files

Article information

Article type
Research Article
Submitted
12 Apr 2023
Accepted
17 May 2023
First published
18 May 2023

Org. Chem. Front., 2023,10, 3061-3066

Cross-coupling of aldehydes and α-bromophosphonates to modularly access α-substituted-β-ketophosphonates under dual nickel/photoredox catalysis

X. Li, H. Wang and T. XU, Org. Chem. Front., 2023, 10, 3061 DOI: 10.1039/D3QO00543G

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