Cross-coupling of aldehydes and α-bromophosphonates to modularly access α-substituted-β-ketophosphonates under dual nickel/photoredox catalysis†
Abstract
β-Ketophosphonates are extremely valuable molecules in organic synthesis. Compared with the numerous synthetic methods for their simple skeletons, the routes for accessing α-substituted-β-ketophosphonates usually need multiple steps with strong bases or harsh conditions. Herein, a modular and direct protocol is reported for these types of compounds by utilizing the easily available aldehydes and α-bromophosphonates via dual nickel/photoredox catalysis. Some special β-keto frameworks were also successfully obtained with this strategy.