Consecutive regulation of catalytic activities of B(C6F5)3·H2O: direct nucleophilic substitution of benzyl fluorides with alcohol via dual activation

Abstract

In order to better understand the activity of boron catalysts, the synthesis of novel structural variants is an important task in boron chemistry, but this could be time-consuming and laborious. Herein we developed a simple strategy for the consecutive regulation of the catalytic activity of B(C₆F₅)₃·H₂O. The acidity of boron water can be changed consecutively by simply adding an appropriate amount of tetrahydrofuran. At the same time, a challenging nucleophilic substitution of benzyl fluoride with alcohol was performed to demonstrate the superiority of this strategy.