Issue 18, 2023

Visible-light-mediated photocatalytic sequential N-arylation: an eco-friendly synthetic route to unsymmetrical diarylamines and the imatinib drug

Abstract

A sustainable protocol for the construction of unsymmetrical diarylamines via a photoredox-mediated dual catalytic copper/ruthenium system has been established. This approach provides easy access to medicinally relevant amines through the sequential arylation of ammonia by utilizing various (hetero)aryl bromides as coupling partners. The resulting in situ generated mono-arylated amines can directly participate in a copper-mediated cross-coupling with aryl boronic acids. Imatinib, a tyrosine kinase inhibitor, is synthesized employing this strategy in an eco-friendly manner.

Graphical abstract: Visible-light-mediated photocatalytic sequential N-arylation: an eco-friendly synthetic route to unsymmetrical diarylamines and the imatinib drug

Supplementary files

Article information

Article type
Research Article
Submitted
14 Jun 2023
Accepted
27 Jul 2023
First published
31 Jul 2023

Org. Chem. Front., 2023,10, 4573-4580

Visible-light-mediated photocatalytic sequential N-arylation: an eco-friendly synthetic route to unsymmetrical diarylamines and the imatinib drug

S. Sana, S. Dastari, D. S. Reddy, R. Tokala, M. Sathish, R. Sonti and N. Shankaraiah, Org. Chem. Front., 2023, 10, 4573 DOI: 10.1039/D3QO00894K

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