Iron-photocatalyzed double decarboxylative coupling reactions of alkynoic acids and alkyl carboxylic acids: access to alkylated alkynes

Abstract

An efficient iron-photocatalyzed approach for the double decarboxylative coupling of alkynoic acids and alkyl carboxylic acids was developed to provide facile access to alkylated alkynes. When alkynoic and alkyl carboxylic acids were reacted in CH₃CN at room temperature, the Fe(NO₃)₃·9H₂O or FeCl₂/TPA catalyst exhibited good activity in the presence of PhI(OAc)₂ under blue light conditions. This iron-photocatalytic decarboxylative coupling system exhibited good functional-group tolerance and good activity toward primary, secondary, and tertiary alkyl carboxylic acids.