Iodine(iii)-catalyzed dehydrogenative cycloisomerization–arylation sequence of 2-propargyl 1,3-dicarbonyl compounds

Abstract

Tandem cycloisomerization-coupling reaction of a nucleophile-tethered alkyne with a coupling partner provides an efficient method that allows the construction of a cyclic skeleton concomitant with the introduction of a functional group, and its dehydrogenative version is a greener approach that does not require a prefunctionalization step of the coupling partner. Herein, we report the dehydrogenative cycloisomerization–arylation sequence of 2-propargyl 1,3-dicarbonyl compounds with unfunctionalized arenes, representing the first report of the dehydrogenative cycloisomerization–functionalization reaction of alkynyl ketones.