Issue 1, 2023

Strebluses E–H, four new stilbene-like derivatives from the stems of Streblus ilicifolius

Abstract

Following bioactivity-guided isolation, four new stilbene-like derivatives, named Strebluses E–H, were isolated from the EtOAc-soluble fraction of the stems of Streblus ilicifolius (Moraceae). Their chemical structures were elucidated based on NMR spectroscopic data interpretation and optical rotation calculation. Streblus E possesses potent tyrosinase inhibitory activity with an IC50 value of 0.1 μM. Oxy-tyrosinase has two bound Cu2+ ions and a peroxide group in the binding site, which has a role in the catalytic oxidation. Thus, a docking study of Streblus E with oxy-tyrosinase was performed to analyze the ligand–protein interactions. With in silico modelling, the S value and the ligand–protein interactions suggested that Streblus E showed lower binding affinity for oxy-tyrosinase than that of Streblus C.

Graphical abstract: Strebluses E–H, four new stilbene-like derivatives from the stems of Streblus ilicifolius

Supplementary files

Article information

Article type
Paper
Submitted
16 Nov 2022
Accepted
09 Dec 2022
First published
22 Dec 2022
This article is Open Access
Creative Commons BY license

RSC Adv., 2023,13, 570-574

Strebluses E–H, four new stilbene-like derivatives from the stems of Streblus ilicifolius

T. H. Le, P. H. Dang, H. X. Nguyen, T. N. V. Do, N. T. Nguyen and M. T. T. Nguyen, RSC Adv., 2023, 13, 570 DOI: 10.1039/D2RA07294G

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