Issue 6, 2023, Issue in Progress

Novel albumin-binding photodynamic agent EB-Ppa for targeted fluorescent imaging guided tumour photodynamic therapy

Abstract

The targeted and novel albumin-binding strategy has been attractive in the field of cancer therapy. Herein, we have developed an organic small molecule-based photosensitizer, Evans Blue-Pyropheophorbide-alpha (EB-Ppa), to treat solid tumors with extremely high photodynamic therapeutic efficiency, which is stable in serum-containing aqueous media and can effectively accumulate in the tumor site due to the enhanced permeability and retention (EPR) effect. Particularly, after the photodynamic therapeutic treatment with EB-Ppa, all breast tumors (4T1 cell line) xenografted in nude mice shrink fast due to the singlet oxygen generated by EB-Ppa with laser irradiation. Furthermore, EB-Ppa shows negligible toxicity in major organs. These results demonstrate that EB-Ppa presents the great potential of photodynamic therapy for efficient tumor treatment.

Graphical abstract: Novel albumin-binding photodynamic agent EB-Ppa for targeted fluorescent imaging guided tumour photodynamic therapy

Supplementary files

Article information

Article type
Paper
Submitted
20 Nov 2022
Accepted
13 Jan 2023
First published
25 Jan 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 3534-3540

Novel albumin-binding photodynamic agent EB-Ppa for targeted fluorescent imaging guided tumour photodynamic therapy

H. Liu, C. Yu, M. Lyu, S. Lyu, L. Hu, E. Xiao and P. Xu, RSC Adv., 2023, 13, 3534 DOI: 10.1039/D2RA07380C

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