Direct fluoroalkylthiolation of indoles with iodofluoroethane enabled by Na2S2O4

Abstract

In this paper, we report an efficient approach for the direct fluoroalkylthiolation of indoles with iodofluoroethane in the presence of Na₂S₂O₄. In this work, we employed readily available iodofluoroethane and Na₂S₂O₄ as fluoroalkylthiolation reagents, featuring mild conditions and a wide range of indole substrates. In addition, fluoroalkylthiolated 2,3′-biindole derivatives can also be prepared by this method.