Issue 12, 2023

Each side chain of cyclosporin A is not essential for high passive permeability across lipid bilayers

Abstract

We compared the passive permeability of cyclosporin A (CsA) derivatives with side chain deletions across lipid bilayers. CsA maintained passive permeability after losing any one of the side chains, which suggests that the propensity of the backbone of CsA is an important component for high passive permeability.

Graphical abstract: Each side chain of cyclosporin A is not essential for high passive permeability across lipid bilayers

Supplementary files

Article information

Article type
Paper
Submitted
28 Feb 2023
Accepted
03 Mar 2023
First published
13 Mar 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 8394-8397

Each side chain of cyclosporin A is not essential for high passive permeability across lipid bilayers

T. Ono, K. V. Tabata, H. Noji, J. Morimoto and S. Sando, RSC Adv., 2023, 13, 8394 DOI: 10.1039/D3RA01358H

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