Association behavior and physico-chemical parameters of a cetylpyridinium bromide and levofloxacin hemihydrate mixture in aqueous and additive media

Abstract

The investigation of the micellization of a mixture of cetylpyridinium bromide (CPB) and levofloxacin hemihydrate (LFH) was carried out by a conductivity technique in aqueous and aq. additive mixtures, including NaCl, NaOAc, NaBenz, 4-ABA, and urea. The aggregation behavior of the CPB + LFH mixture was studied considering the variation in additive contents and the change in experimental temperature. The micelle formation of the CPB + LFH mixture was examined from the breakpoint observed in the specific conductivity versus surfactant concentration plots. Different micellar characteristics, such as the critical micelle concentration (CMC) and the extent of counter ion bound (β), were evaluated for the CPB + LFH mixture. The CMC and β were found to undergo a change with the types of solvents, composition of solvents, and working temperatures. The ΔG⁰_m values of the CPB + LFH system in aqueous and aq. additive solutions were found to be negative, which denotes a spontaneous aggregation phenomenon of the CPB + LFH system. The changes in ΔH⁰_m and ΔS⁰_m for the CPB + LFH mixture were also detected with the alteration in the solvent nature and solution temperature. The ΔH⁰_m and ΔS⁰_m values obtained for the association of the CPB + LFH mixture reveal that the characteristic interaction forces may possibly be ion–dipole, dipole–dipole, and hydrophobic between CPB and LFH. The thermodynamics of transfer and ΔH⁰_m–ΔS⁰_m compensation variables were also determined. All the parameters computed in the present investigation are illustrated with proper logic.