Issue 27, 2023

A fruitful century for the scalable synthesis and reactions of biphenyl derivatives: applications and biological aspects

Abstract

This review provides recent developments in the current status and latest synthetic methodologies of biphenyl derivatives. Furthermore, this review investigates detailed discussions of several metalated chemical reactions related to biphenyl scaffolds such as Wurtz–Fittig, Ullmann, Bennett–Turner, Negishi, Kumada, Stille, Suzuki–Miyaura, Friedel–Crafts, cyanation, amination, and various electrophilic substitution reactions supported by their mechanistic pathways. Furthermore, the preconditions required for the existence of axial chirality in biaryl compounds are discussed. Furthermore, atropisomerism as a type of axial chirality in biphenyl molecules is discussed. Additionally, this review covers a wide range of biological and medicinal applications of the synthesized compounds involving patented approaches in the last decade corresponding to investigating the crucial role of the biphenyl structures in APIs.

Graphical abstract: A fruitful century for the scalable synthesis and reactions of biphenyl derivatives: applications and biological aspects

Article information

Article type
Review Article
Submitted
26 May 2023
Accepted
10 Jun 2023
First published
16 Jun 2023
This article is Open Access
Creative Commons BY license

RSC Adv., 2023,13, 18262-18305

A fruitful century for the scalable synthesis and reactions of biphenyl derivatives: applications and biological aspects

H. A. Ali, M. A. Ismail, A. E. S. Fouda and E. A. Ghaith, RSC Adv., 2023, 13, 18262 DOI: 10.1039/D3RA03531J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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