Issue 32, 2023

The Mizoroki–Heck reaction between in situ generated alkenes and aryl halides: cross-coupling route to substituted olefins

Abstract

This review covers palladium-catalyzed typical Mizoroki–Heck cross-coupling reactions of aryl halides with in situ generated alkenes, by following a typical Heck coupling mechanism to form substituted olefins unlike direct cross-coupling of alkenes with aryl halides in Heck olefination. These reactions solve the issue of alkenes undergoing polymerization at high temperatures and increase reaction efficiency by reducing the reaction time and purification steps.

Graphical abstract: The Mizoroki–Heck reaction between in situ generated alkenes and aryl halides: cross-coupling route to substituted olefins

Article information

Article type
Review Article
Submitted
26 May 2023
Accepted
18 Jul 2023
First published
25 Jul 2023
This article is Open Access
Creative Commons BY license

RSC Adv., 2023,13, 22512-22528

The Mizoroki–Heck reaction between in situ generated alkenes and aryl halides: cross-coupling route to substituted olefins

A. Koranne, S. Turakhia, V. K. Jha, S. Gupta, R. Ravi, A. Mishra, A. K. Aggarwal, C. K. Jha, N. Dheer and A. K. Jha, RSC Adv., 2023, 13, 22512 DOI: 10.1039/D3RA03533F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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