Utilizing a nanocomposite aerogel grafted with Fe3O4@GO for the extraction and determination of metoprolol in exhaled breath condensate

Bita Azad; Zahra Karimzadeh; Amirreza Jabbaripour; Vahid Jouyban-Gharamaleki; Maryam Khoubnasabjafari; Abolghasem Jouyban; Elaheh Rahimpour

doi:10.1039/D3RA03883A

Utilizing a nanocomposite aerogel grafted with Fe₃O₄@GO for the extraction and determination of metoprolol in exhaled breath condensate†

Bita Azad,^ab Zahra Karimzadeh,^ab Amirreza Jabbaripour,^c Vahid Jouyban-Gharamaleki,^d Maryam Khoubnasabjafari,^ef Abolghasem Jouyban^ag and Elaheh Rahimpour

*^ah

Author affiliations

* Corresponding authors

^a Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
E-mail: Rahimpour_e@yahoo.com

^b Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

^c Faculty of Medicine, Tabriz Azad Islamic University, Tabriz, Iran

^d Kimia Idea Pardaz Azarbayjan (KIPA) Science Based Company, Tabriz University of Medical Sciences, Tabriz, Iran

^e Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Science, Tabriz, Iran

^f Department of Anesthesiology and Intensive Care, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

^g Pharmaceutical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

^h Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

This article presents a solid-phase extraction method combined with a spectrofluorometric method for the extraction/pre-concentration and determination of metoprolol (MET) in exhaled breath condensate. The extraction sorbent is an agarose aerogel nanocomposite grafted with graphene oxide (GO) Fe₃O₄. The size and morphology of the nanosorbent were characterized via X-ray crystallography, scanning electron microscopy, Fourier-transform infrared spectrometry, and Brunauer–Emmett–Teller analysis. Factors affecting the extraction/determination of MET were optimized using the one-at-a-time method. Under optimized experimental conditions, the calibration graph was linear in the range of 0.005 to 2.0 μg mL⁻¹ with a detection limit of 0.001 μg mL⁻¹. The method was successfully applied for the determination of MET in biological samples taken from patients receiving MET.

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Article information

DOI: https://doi.org/10.1039/D3RA03883A
Article type: Paper
Submitted: 10 Jun 2023
Accepted: 02 Oct 2023
First published: 18 Oct 2023
This article is Open Access

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RSC Adv., 2023,13, 30562-30574

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Utilizing a nanocomposite aerogel grafted with Fe₃O₄@GO for the extraction and determination of metoprolol in exhaled breath condensate

B. Azad, Z. Karimzadeh, A. Jabbaripour, V. Jouyban-Gharamaleki, M. Khoubnasabjafari, A. Jouyban and E. Rahimpour, RSC Adv., 2023, 13, 30562 DOI: 10.1039/D3RA03883A

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