Issue 39, 2023, Issue in Progress

pH-Sensitive nanodiamond co-delivery of retinal and doxorubicin boosts breast cancer chemotherapy

Abstract

Herein for the first time we take the advantage of nanodiamonds (NDs) to covalently immobilize all-trans retinal (NPA) by an imine bond, allowing pH-mediated drug release. DOX is then physically adsorbed onto NPA to form an NPA@D co-loaded double drug in the sodium citrate medium, which is also susceptible to pH-triggered DOX dissociation. The cytotoxicity results showed that NPA@D could markedly inhibit the growth of DOX-sensitive MCF-7 cells in a synergetic way compared to the NP@D system of single-loaded DOX, while NPA basically showed no cytotoxicity and weak inhibition of migration. In addition, NPA@D can overcome the drug resistance of MCF-7/ADR cells, indicating that this nanodrug could evade the pumping of DOX by drug-resistant cells, but free DOX is nearly ineffective against these cells. More importantly, the fluorescence imaging of tumor-bearing mice in vivo and ex vivo demonstrated that the NPA@D was mainly accumulated in the tumor site rather than any other organ by intraperitoneal injection after 24 h, in which the fluorescence intensity of NPA@D was 19 times that of the free DOX, suggesting that a far reduced off-target effect and side effects would be expected. Therefore, this work presents a new paradigm for improving chemotherapy and reversing drug resistance using the ND platform for co-delivery of DOX and ATR.

Graphical abstract: pH-Sensitive nanodiamond co-delivery of retinal and doxorubicin boosts breast cancer chemotherapy

Supplementary files

Article information

Article type
Paper
Submitted
11 Jun 2023
Accepted
28 Aug 2023
First published
13 Sep 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 27403-27414

pH-Sensitive nanodiamond co-delivery of retinal and doxorubicin boosts breast cancer chemotherapy

J. Cui, B. Hu, Y. Fu, Z. Xu and Y. Li, RSC Adv., 2023, 13, 27403 DOI: 10.1039/D3RA03907B

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