Sustainable continuous flow synthesis of β-aminocarbonyls via acid-catalyzed hydration of N-Boc-2-azetines

Michael Andresini; Marco Colella; Roberta Savina Dibenedetto; Elena Graziano; Giuseppe Romanazzi; Andrea Aramini; Leonardo Degennaro; Renzo Luisi

doi:10.1039/D3RE00342F

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Sustainable continuous flow synthesis of β-aminocarbonyls via acid-catalyzed hydration of N-Boc-2-azetines†

Michael Andresini,

‡^a Marco Colella,

‡^a Roberta Savina Dibenedetto,^a Elena Graziano,^a Giuseppe Romanazzi,

^b Andrea Aramini,

^c Leonardo Degennaro

*^a and Renzo Luisi

*^a

Author affiliations

* Corresponding authors

^a FLAME-Lab, Flow Chemistry and Microreactor Technology Laboratory Department of Pharmacy – Drug Sciences University of Bari “A. Moro”, Via E. Orabona 4 – 70125 Bari, Italy
E-mail: renzo.luisi@uniba.it

^b DICATECh, Politecnico di Bari, Via E. Orabona, 4 – 70125 Bari, Italy

^c Department of Discovery, Dompé Farmaceutici S.p.A, Via Campo di Pile, L'Aquila I-67100, Italy

Abstract

In this work we report a waste-minimized continuous flow process for the synthesis of β-aminocarbonyls through hydration of N-Boc-2-azetines promoted under acid-catalysed conditions. The greenness of the process is harnessed by the use of flow technology for handling a biphasic segmented flow and the use of an inline liquid–liquid separator allowing the recovery of both the eco-friendly organic solvent (CPME) and the reusable acidic aqueous phase.

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Article information

DOI: https://doi.org/10.1039/D3RE00342F
Article type: Paper
Submitted: 21 Jun 2023
Accepted: 12 Jul 2023
First published: 13 Sep 2023
This article is Open Access

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React. Chem. Eng., 2023,8, 3203-3209

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Sustainable continuous flow synthesis of β-aminocarbonyls via acid-catalyzed hydration of N-Boc-2-azetines

M. Andresini, M. Colella, R. S. Dibenedetto, E. Graziano, G. Romanazzi, A. Aramini, L. Degennaro and R. Luisi, React. Chem. Eng., 2023, 8, 3203 DOI: 10.1039/D3RE00342F

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Reaction Chemistry & Engineering

Sustainable continuous flow synthesis of β-aminocarbonyls via acid-catalyzed hydration of N-Boc-2-azetines†

Abstract

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Article information

Download Citation

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Sustainable continuous flow synthesis of β-aminocarbonyls via acid-catalyzed hydration of N-Boc-2-azetines

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