Issue 27, 2023

A focus on sustainable method development for greener synthesis

Abstract

Given the current global climate and health challenges, sustainability and cost-effectiveness are becoming unavoidable factors that must be considered in the development of new synthetic methodologies. In a recent publication, Kavthe et al. (R. D. Kavthe, K. S. Iyer, J. C. Caravez and B. H. Lipshutz, Chem. Sci., 2023, 14, 6399, https://doi.org/10.1039/D3SC01699D) have succinctly demonstrated how employing more sustainable methodology can vastly reduce the environmental impact associated with the synthesis of the antimalarial drug candidate MMV688533. The most notable feature of this newly reported synthetic route is the application of aqueous micellar conditions to two Sonogashira coupling reactions that simultaneously improve the yield, catalyst loading and sustainability of these key steps.

Graphical abstract: A focus on sustainable method development for greener synthesis

Article information

Article type
Commentary
First published
29 Jun 2023
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2023,14, 7408-7410

A focus on sustainable method development for greener synthesis

J. L. Tyler, F. Katzenburg and F. Glorius, Chem. Sci., 2023, 14, 7408 DOI: 10.1039/D3SC90120C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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