Issue 4, 2024

Zwitterionic oligomers of 3-aminobenzoic acid on screen-printed electrodes: structure, properties and forensic application

Abstract

The popularity and rapid spread of new psychoactive substances is why there is an urgent need for their fast monitoring in saliva in the field with electrodes modified with a selective receptor. Oligomers of electrochemically oxidized 3-aminobenzoic acid that are deposited on the surface of a graphite screen-printed electrode (o-3ABA/G/SPE) is proposed as a selector for the analyte of forensic interest. The oligomeric structure and existence of the zwitterionic form of o-3ABA on the G/SPE surface was confirmed using scanning electron microscopy, Raman spectroscopy and cyclic voltammetry techniques. The equilibrium adsorption constants between o-3ABA and 2-aminoindane (primary amine: Kads(2-AI) = 5.31 × 104) and selected synthetic cathinones (secondary amine: Kads(butylone) = 6.12 × 105, tertiary amines: Kads(MDPV) = 3.41 × 104 and Kads(naphyrone) = 1.01 × 104) were estimated using the electrochemical impedance spectroscopy (EIS) technique. The EIS technique was applied for determining a 1.0 μM concentration of 2-AI (RSD 3.5–4.0%) and butylone (RSD 4.9–6.4%) in the model and oral fluid samples.

Graphical abstract: Zwitterionic oligomers of 3-aminobenzoic acid on screen-printed electrodes: structure, properties and forensic application

Supplementary files

Article information

Article type
Paper
Submitted
06 Oct 2023
Accepted
19 Dec 2023
First published
11 Jan 2024
This article is Open Access
Creative Commons BY-NC license

Analyst, 2024,149, 1121-1131

Zwitterionic oligomers of 3-aminobenzoic acid on screen-printed electrodes: structure, properties and forensic application

T. V. Shishkanova, E. Pospíšilová, M. Trchová and G. Broncová, Analyst, 2024, 149, 1121 DOI: 10.1039/D3AN01700A

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