Issue 2, 2024

Discovery and engineering of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products

Abstract

Ribosomally synthesized and post-translationally modified peptides (RiPPs) represent a diverse superfamily of natural products with immense potential for drug development. This review provides a concise overview of the recent advances in the discovery of RiPP natural products, focusing on rational strategies such as bioactivity guided screening, enzyme or precursor-based genome mining, and biosynthetic engineering. The challenges associated with activating silent biosynthetic gene clusters and the development of elaborate catalytic systems are also discussed. The logical frameworks emerging from these research studies offer valuable insights into RiPP biosynthesis and engineering, paving the way for broader pharmaceutic applications of these peptide natural products.

Graphical abstract: Discovery and engineering of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products

Article information

Article type
Review Article
Submitted
07 Sep 2023
Accepted
17 Nov 2023
First published
21 Nov 2023
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2024,5, 90-108

Discovery and engineering of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products

H. Li, W. Ding and Q. Zhang, RSC Chem. Biol., 2024, 5, 90 DOI: 10.1039/D3CB00172E

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