We report a greener peptide coupling using bicyclic benziodazolone and triarylphosphine as coupling reagents. Bicyclic benziodazolone also works as a base and can be recovered as the corresponding iodine(I) compound after use, which can be converted to the original iodine(III) reagent by electrolytic oxidation.
D. Uehara, S. Adachi, A. Tsubouchi, Y. Okada, V. V. Zhdankin, A. Yoshimura and A. Saito, Chem. Commun., 2024, 60, 956 DOI: 10.1039/D3CC04431A
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