Acceleration of hydrolytic ring opening of N7-alkylguanine by the terminal carbamoyl group of glycidamide

Abstract

Hydrolytic ring opening of guanine N7-adducts with compounds containing an oxacyclopropane ring, namely glycidamide, glycidol and 1,2-epoxybutane, was analyzed, and the reaction of the glycidamide adduct was the fastest. The differences in the reaction rates were confirmed by theoretical calculations.