Issue 4, 2024
From the journal:

Chemical Communications

Nickel-catalyzed regioselective hydrogen isotope exchange accelerated by 2-pyridones†

Zhi-Jiang Jiang, ORCID logo *a   Si-Han Xu,ab   Yuhang Su,ab   Erxun Hu,a   Jiawei Han,ab   Jian-Fei Bai,a   Bencan Tang, ORCID logo d   Jia Chenac  and  Zhanghua Gao ORCID logo *ac  

* Corresponding authors

a NingboTech-Cuiying Joint Laboratory of Stable Isotope Technology, School of Biological and Chemical Engineering, NingboTech University, Ningbo, P. R. China
E-mail: zj.jiang@nbt.edu.cn, z.gao@nbt.edu.cn

b School of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P. R. China

c Ningbo Cuiying Chemical Technology Co. Ltd., Ningbo, P. R. China

d Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, P. R. China

Abstract

A nickel-catalyzed hydrogen isotope exchange has been developed with acetone-d6 as the deuterium source. The reaction showed an improved kinetic feature of H/D exchange under the assistance of 2-pyridones, efficiently affording regioselective labeled aryl and alkyl carboxamides.

Graphical abstract: Nickel-catalyzed regioselective hydrogen isotope exchange accelerated by 2-pyridones

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Article information

DOI
https://doi.org/10.1039/D3CC05257E
Article type
Communication
Submitted
26 Oct 2023
Accepted
17 Nov 2023
First published
27 Nov 2023

Chem. Commun., 2024,60, 384-387

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Nickel-catalyzed regioselective hydrogen isotope exchange accelerated by 2-pyridones

Z. Jiang, S. Xu, Y. Su, E. Hu, J. Han, J. Bai, B. Tang, J. Chen and Z. Gao, Chem. Commun., 2024, 60, 384 DOI: 10.1039/D3CC05257E

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