Issue 11, 2024
From the journal:

Chemical Communications

A reductively convertible nickel phthalocyanine precursor as a biological thiol-responsive turn-on photoacoustic contrast agent†

Kohei Nogita,a   Takaya Sugahara,a   Koji Miki, ORCID logo *a   Huiying Mu, ORCID logo a   Minoru Kobayashi, ORCID logo b   Hiroshi Harada ORCID logo b  and  Kouichi Ohe ORCID logo *a  

* Corresponding authors

a Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan
E-mail: kojimiki@scl.kyoto-u.ac.jp, ohe@scl.kyoto-u.ac.jp

b Laboratory of Cancer Cell Biology, Graduate School of Biostudies, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan

Abstract

A nickel phthalocyanine precursor bearing poly(ethylene glycol) as a turn-on contrast agent for photoacoustic imaging was prepared. The water-soluble polymeric chains were smoothly eliminated through thiol-mediated reductive aromatization in cancer cells, enabling the detection of endogenous biological thiols in vitro and in vivo.

Graphical abstract: A reductively convertible nickel phthalocyanine precursor as a biological thiol-responsive turn-on photoacoustic contrast agent

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Article information

DOI
https://doi.org/10.1039/D3CC05628G
Article type
Communication
Submitted
16 Nov 2023
Accepted
12 Dec 2023
First published
15 Jan 2024
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2024,60, 1472-1475

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A reductively convertible nickel phthalocyanine precursor as a biological thiol-responsive turn-on photoacoustic contrast agent

K. Nogita, T. Sugahara, K. Miki, H. Mu, M. Kobayashi, H. Harada and K. Ohe, Chem. Commun., 2024, 60, 1472 DOI: 10.1039/D3CC05628G

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