Electrochemical desulfurative formation of C–N bonds through selective activation of inert C(sp3)–S bonds

Abstract

In this study, we introduce an efficient, metal-free electrocatalytic desulfurative protocol for forming C–N bonds by selectively activating inert C(sp³)–S bonds of alkyl thioethers. This method offers a straightforward and environmentally friendly approach for modification of heterocyclic compounds from readily accessible thioethers. Preliminary mechanistic investigations suggest that the reaction proceeds via a carbocation intermediate. Furthermore, successful synthesis on a 10-gram scale was achieved in a continuous flow electrochemical reactor.