Issue 23, 2024

Organometallic modification confers oligonucleotides new functionalities

Abstract

To improve their properties or to introduce entirely new functionalities, the intriguing scaffolds of nucleic acids have been decorated with various modifications, most recently also organometallic ones. While challenging to introduce, organometallic modifications offer the potential of expanding the field of application of metal-dependent functionalities to metal-deficient conditions, notably those of biological media. So far, organometallic moieties have been utilized as probes, labels and catalysts. This Feature Article summarizes recent efforts and predicts likely future developments in each of these lines of research.

Graphical abstract: Organometallic modification confers oligonucleotides new functionalities

Article information

Article type
Feature Article
Submitted
22 Jan 2024
Accepted
15 Feb 2024
First published
16 Feb 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2024,60, 3118-3128

Organometallic modification confers oligonucleotides new functionalities

T. K. Kotammagari, L. Y. Saleh and T. Lönnberg, Chem. Commun., 2024, 60, 3118 DOI: 10.1039/D4CC00305E

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