The enantioselective synthesis of tricyclic oxoquinolines via NHC-catalyzed cascade reaction of enals with malonates bearing a 2-aminophenyl group is reported. The chiral α,β-unsaturated acylazoliums underwent a smooth Michael-aldol-lactamization-dehydration quadruple cascade with the amino malonate derivative to afford the desired tricyclic products.
S. Barik, G. Sankar and A. T. Biju, Chem. Commun., 2024, 60, 4290 DOI: 10.1039/D4CC00502C
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