Issue 49, 2024

Multivalent dendritic DNA aptamer molecules for the enhancement of therapeutic effects

Abstract

Dendritic DNA molecules, referred to as DNA dendrons, consist of multiple covalently linked strands and are expected to improve the cellular uptake and potency of therapeutic oligonucleotides because of their multivalency. In this study, we developed an efficient synthetic method for producing DNA dendrons using strain-promoted azide–alkyne cycloaddition. Integration of the antitumor aptamer AS1411 into DNA dendrons enhanced cellular uptake and antiproliferative activity in cancer cells. These findings demonstrate that the incorporation of multivalent aptamers into DNA dendrons can effectively boost their therapeutic effects.

Graphical abstract: Multivalent dendritic DNA aptamer molecules for the enhancement of therapeutic effects

Supplementary files

Article information

Article type
Communication
Submitted
04 Feb 2024
Accepted
06 May 2024
First published
13 May 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2024,60, 6256-6259

Multivalent dendritic DNA aptamer molecules for the enhancement of therapeutic effects

Y. Kawamoto, Y. Wu, S. Park, K. Hidaka, H. Sugiyama, Y. Takahashi and Y. Takakura, Chem. Commun., 2024, 60, 6256 DOI: 10.1039/D4CC00578C

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