Issue 48, 2024

Electrochemical quinuclidine-mediated Minisci-type acylation of N-heterocycles with aldehydes

Abstract

The electro-generation of acyl radicals from both aromatic and aliphatic aldehydes remains an unmet challenge. We provide a solution to this challenge by merging electro-oxidation and a quinuclidine-mediated hydrogen atom transfer strategy. The generation of acyl radicals at decreased applied potentials compared to that of formyl oxidation exhibits excellent functional group compatibility.

Graphical abstract: Electrochemical quinuclidine-mediated Minisci-type acylation of N-heterocycles with aldehydes

Supplementary files

Article information

Article type
Communication
Submitted
19 Feb 2024
Accepted
17 May 2024
First published
17 May 2024

Chem. Commun., 2024,60, 6174-6177

Electrochemical quinuclidine-mediated Minisci-type acylation of N-heterocycles with aldehydes

Y. Li, L. Sun, S. Huang, K. Xu and C. Zeng, Chem. Commun., 2024, 60, 6174 DOI: 10.1039/D4CC00800F

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