Issue 34, 2024
From the journal:

Chemical Communications

Potential-resolved electrochemiluminescence for simultaneous determination of multiplex bladder cancer markers†

Junke Wang,a   Fenglian Guo,a   Jingjing Zhang*a  and  Jie Chao ORCID logo *ab  

* Corresponding authors

a State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China
E-mail: jingjingzhang@njupt.edu.cn, iamjchao@njupt.edu.cn

b Portland Institute, Nanjing University of Posts and Telecommunications, Nanjing 210023, China

Abstract

A novel ECL immunosensor was developed for simultaneous determination of multiplex bladder cancer markers. DNA tetrahedra act as capture probes, while Ru-MOF@AuNPs and AuAgNCs act as signal reporters, yielding well-separated signals reflecting NUMA1 and CFHR1 concentrations. This strategy offers a new platform for clinical immunoassays, enabling simultaneous multiplex tumor marker detection.

Graphical abstract: Potential-resolved electrochemiluminescence for simultaneous determination of multiplex bladder cancer markers

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Article information

DOI
https://doi.org/10.1039/D4CC00996G
Article type
Communication
Submitted
01 Mar 2024
Accepted
30 Mar 2024
First published
01 Apr 2024

Chem. Commun., 2024,60, 4609-4612

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Potential-resolved electrochemiluminescence for simultaneous determination of multiplex bladder cancer markers

J. Wang, F. Guo, J. Zhang and J. Chao, Chem. Commun., 2024, 60, 4609 DOI: 10.1039/D4CC00996G

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