Towards tailoring hydrophobic interaction with uranyl(VI) oxygen for C–H activation

Satoru Tsushima; Jérôme Kretzschmar; Hideo Doi; Koji Okuwaki; Masashi Kaneko; Yuji Mochizuki; Koichiro Takao

doi:10.1039/D4CC01030B

Towards tailoring hydrophobic interaction with uranyl(vi) oxygen for C–H activation†

Satoru Tsushima,

*^ab Jérôme Kretzschmar,

^a Hideo Doi,^c Koji Okuwaki,

^c Masashi Kaneko,

^d Yuji Mochizuki

^de and Koichiro Takao

Author affiliations

* Corresponding authors

^a Institute of Resource Ecology, Helmholtz–Zentrum Dresden–Rossendorf (HZDR), Dresden, Germany
E-mail: s.tsushima@hzdr.de

^b International Research Frontiers Initiative (IRFI), Institute of Innovative Research, Tokyo Institute of Technology, Tokyo, Japan

^c Department of Chemistry and Research Center for Smart Molecules, Rikkyo University, Tokyo, Japan

^d Department of Chemistry, Osaka University, Osaka, Japan

^e Institute of Industrial Science, The University of Tokyo, Tokyo, Japan

^f Laboratory for Zero-Carbon Energy, Institute of Innovative Research, Tokyo Institute of Technology, Tokyo, Japan

Abstract

Bovine serum albumin (BSA) has a uranyl(VI) binding hotspot where uranium is tightly bound by three carboxylates. Uranyl oxygen is “soaked” into the hydrophobic core of BSA. Isopropyl hydrogen of Val is trapped near UO₂²⁺ and upon photoexcitation, C–H bond cleavage is initiated. A unique hydrophobic contact with “yl”-oxygen, as observed here, can be used to induce C–H activation.

Supplementary files

Article information

DOI: https://doi.org/10.1039/D4CC01030B
Article type: Communication
Submitted: 05 Mar 2024
Accepted: 25 Mar 2024
First published: 25 Mar 2024
This article is Open Access

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Chem. Commun., 2024,60, 4769-4772

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Towards tailoring hydrophobic interaction with uranyl(VI) oxygen for C–H activation

S. Tsushima, J. Kretzschmar, H. Doi, K. Okuwaki, M. Kaneko, Y. Mochizuki and K. Takao, Chem. Commun., 2024, 60, 4769 DOI: 10.1039/D4CC01030B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Chemical Communications

Towards tailoring hydrophobic interaction with uranyl(vi) oxygen for C–H activation†

Abstract

Supplementary files

Article information

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Towards tailoring hydrophobic interaction with uranyl(VI) oxygen for C–H activation

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