Issue 41, 2024
From the journal:

Chemical Communications

An AIE-based fluorescent probe to detect peroxynitrite levels in human serum and its cellular imaging†

Jaewon Kim, ORCID logo ‡a   Jiyoung Yoo,‡a   Byungkook Kim,‡a   Kyung-Woo Lee, ORCID logo ‡a   Sunghyun Kim,b   Sukwon Hong ORCID logo *b  and  Jong Seung Kim ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Seoul, Korea University, Korea
E-mail: jongskim@korea.ac.kr

b Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju, Korea
E-mail: shong@gist.ac.kr

Abstract

An AIE-based fluorescent probe was designed to evaluate peroxynitrite levels in complex biological samples. The newly synthesized hydrazone-conjugated probe fluoresces strongly in the presence of peroxynitrite. Clinically, the peroxynitrite levels can be measured in human serum and cellular mitochondria with an LOD of 6.5 nM by fluorescence imaging in vitro.

Graphical abstract: An AIE-based fluorescent probe to detect peroxynitrite levels in human serum and its cellular imaging

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Article information

DOI
https://doi.org/10.1039/D4CC01231C
Article type
Communication
Submitted
17 Mar 2024
Accepted
23 Apr 2024
First published
25 Apr 2024

Chem. Commun., 2024,60, 5443-5446

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An AIE-based fluorescent probe to detect peroxynitrite levels in human serum and its cellular imaging

J. Kim, J. Yoo, B. Kim, K. Lee, S. Kim, S. Hong and J. S. Kim, Chem. Commun., 2024, 60, 5443 DOI: 10.1039/D4CC01231C

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