Iron-catalyzed benzylic C–H thiolation via photoinduced ligand-to-metal charge-transfer

Kaiting Sun; Tianyi Sun; Yuxin Jiang; Jiayue Shi; Wenlu Sun; Youyou Zheng; Zhixuan Wang; Ziyu Li; Xiaoqing Lv; Xingxian Zhang; Fan Luo; Shihui Liu

doi:10.1039/D4CC01574F

Iron-catalyzed benzylic C–H thiolation via photoinduced ligand-to-metal charge-transfer†

Kaiting Sun,‡^ab Tianyi Sun,‡^ab Yuxin Jiang,‡^b Jiayue Shi,^b Wenlu Sun,^b Youyou Zheng,^b Zhixuan Wang,^b Ziyu Li,^b Xiaoqing Lv,

^b Xingxian Zhang,*^a Fan Luo

*^b and Shihui Liu

*^b

Author affiliations

* Corresponding authors

^a College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P. R. China
E-mail: zhangxx@zjut.edu.cn

^b College of Medicine, Jiaxing University, 118 Jiahang Road, Jiaxing, P. R. China
E-mail: luofan@zjxu.edu.cn, liushihui12310@zjxu.edu.cn

Abstract

Here, we describe an iron-catalyzed benzylic C–H thiolation of alkylarenes via photoinduced ligand-to-metal charge-transfer. The protocol features operational simplicity, mild reaction conditions, and the use of FeCl₃ as catalyst and thiols/disulfides as sulfur sources, which enables the transformation of diverse benzylic C–H bonds into C–S bonds with a high efficiency.

Chemical Communications

Iron-catalyzed benzylic C–H thiolation via photoinduced ligand-to-metal charge-transfer†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Iron-catalyzed benzylic C–H thiolation via photoinduced ligand-to-metal charge-transfer

Social activity

Search articles by author

Spotlight

Advertisements