Issue 49, 2024

Direct C–H alkylation of 3,4-dihydroquinoxaline-2-ones with N-(acyloxy)phthalimides via radical–radical cross coupling

Abstract

We present an organophotoredox-catalyzed direct Csp3–H alkylation of 3,4-dihydroquinoxalin-2-ones employing N-(acyloxy)pthalimides to provide corresponding products in good yields. A broad spectrum of NHPI esters (1°, 2°, 3°, and sterically encumbered) participates in the photoinduced alkylation of a variety of 3,4-dihydroquinoxalin-2-ones. In general, mild conditions, broad scope with good functional group tolerance, and scalability are the salient features of this direct alkylation process.

Graphical abstract: Direct C–H alkylation of 3,4-dihydroquinoxaline-2-ones with N-(acyloxy)phthalimides via radical–radical cross coupling

Supplementary files

Article information

Article type
Communication
Submitted
18 Apr 2024
Accepted
22 May 2024
First published
23 May 2024

Chem. Commun., 2024,60, 6268-6271

Direct C–H alkylation of 3,4-dihydroquinoxaline-2-ones with N-(acyloxy)phthalimides via radical–radical cross coupling

S. K. Hota, G. Singh and S. Murarka, Chem. Commun., 2024, 60, 6268 DOI: 10.1039/D4CC01837K

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