Issue 48, 2024

Synthesis of thioesters using an electrochemical three-component reaction involving elemental sulfur

Abstract

An electrochemical three-component reaction involving elemental sulfur is disclosed for achieving a metal-free, oxidant-free synthesis of thioesters in a high atom-economical, step-economical and chemoselective manner. A mechanistic investigation indicates that the use of elemental sulfur to trap acyl radical derived from radical umpolung of α-keto acid with an electrochemical design can efficiently generate a carbonyl thiyl radical, which can further be captured by diazoalkane to afford various thioesters.

Graphical abstract: Synthesis of thioesters using an electrochemical three-component reaction involving elemental sulfur

Supplementary files

Article information

Article type
Communication
Submitted
23 Apr 2024
Accepted
13 May 2024
First published
14 May 2024

Chem. Commun., 2024,60, 6154-6157

Synthesis of thioesters using an electrochemical three-component reaction involving elemental sulfur

G. Liu, S. Xu, Y. Yue, C. Su and W. Song, Chem. Commun., 2024, 60, 6154 DOI: 10.1039/D4CC01910E

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