A splice-switch oligonucleotide loaded self-cleavable DNA nanogel

Yuwei Hu; Feng Chen; Hongfang Lu; Susi Tan; Yujie Ke; Wei Wei Loh; Eugene Jia Hao Soh; Agarwal Taniya; Tommaso Tabaglio; Dave Keng Boon Wee; Jackie Y. Ying

doi:10.1039/D4CC01942C

A splice-switch oligonucleotide loaded self-cleavable DNA nanogel†

Yuwei Hu,

*^ab Feng Chen,^abc Hongfang Lu,

^abd Susi Tan,

^abd Yujie Ke,^ae Wei Wei Loh,

^a Eugene Jia Hao Soh,

^a Agarwal Taniya,^d Tommaso Tabaglio,^d Dave Keng Boon Wee^d and Jackie Y. Ying

*^abf

Author affiliations

* Corresponding authors

^a Institute of Materials Research and Engineering (IMRE), Agency for Science Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, Singapore 138634, Republic of Singapore
E-mail: ywhu@imre.a-star.edu.sg

^b NanoBio Lab, A*STAR, 31 Biopolis Way, The Nanos, #09-01, Singapore 138669, Republic of Singapore

^c Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), A*STAR, 1 Pesek Road Jurong Island, Singapore 627833, Republic of Singapore

^d Institute of Molecular and Cell Biology, A*STAR, 61 Biopolis Drive, The Proteos, Singapore 138673, Republic of Singapore

^e School of Interdisciplinary Studies, Lingnan University, Tuen Mun, Hong Kong SAR, China

^f Bioengineering and Nanomedicine Department, King Faisal Specialist Hospital & Research Centre, Riyadh 11211, Saudi Arabia
E-mail: jying@kfshrc.edu.sa

Abstract

A self-cleavable DNA nanogel loaded with splice-switch oligonucleotide (SSO) has been developed. Under acidic conditions (pH 5.0), cleavage of the acid-labile chemical linker and generation of the i-motif structure led to the disintegration of the DNA nanogel and efficient release of SSO in its unaltered native state.

Chemical Communications

A splice-switch oligonucleotide loaded self-cleavable DNA nanogel†

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A splice-switch oligonucleotide loaded self-cleavable DNA nanogel

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