Design of a high-performance NIR-II nanoprobe by steric regulation for in vivo vasculature and tumor imaging

Yu Wang; Yuxin Duan; Chenxing Gong; Yuhang Li; Meilin Xu; Miao Liu; Wenxu Liu; Xiaole Zhou; Leyu Wang

doi:10.1039/D4CC02224F

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Design of a high-performance NIR-II nanoprobe by steric regulation for in vivo vasculature and tumor imaging†

Yu Wang,‡^a Yuxin Duan,‡^a Chenxing Gong,^a Yuhang Li,^a Meilin Xu,^a Miao Liu,^b Wenxu Liu,*^a Xiaole Zhou

*^a and Leyu Wang

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, P. R. China
E-mail: lywang@mail.buct.edu.cn, zhouxiaole@buct.edu.cn, liuwenxu@buct.edu.cn

^b Department of Pharmacy, Northeast International Hospital Huanggu District, Shenyang, P. R. China

Abstract

A novel NIR-II nanoprobe was developed through regulating the steric effect of an A–DA′D–A dye. The probe features the properties of strong fluorescence, high stability, and a large Stokes shift, thereby serving as a remarkable contrast agent for the fluorescence imaging of hindlimb vasculature and tumors in live mice.

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Article information

DOI: https://doi.org/10.1039/D4CC02224F
Article type: Communication
Submitted: 08 May 2024
Accepted: 25 Jun 2024
First published: 03 Jul 2024

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Chem. Commun., 2024,60, 8059-8062

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Design of a high-performance NIR-II nanoprobe by steric regulation for in vivo vasculature and tumor imaging

Y. Wang, Y. Duan, C. Gong, Y. Li, M. Xu, M. Liu, W. Liu, X. Zhou and L. Wang, Chem. Commun., 2024, 60, 8059 DOI: 10.1039/D4CC02224F

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Chemical Communications

Design of a high-performance NIR-II nanoprobe by steric regulation for in vivo vasculature and tumor imaging†

Abstract

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Design of a high-performance NIR-II nanoprobe by steric regulation for in vivo vasculature and tumor imaging

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