Issue 58, 2024
From the journal:

Chemical Communications

A lateral flow assay strip for simultaneous detection of miRNA and exosomes in liver cancer†

Ruyue Wei,‡a   Dawei Wang,‡c   Ping Zhou,a   Yingbo Pan,a   Xiuyan Wan,a   Wei Pan, ORCID logo a   Na Li ORCID logo *a  and  Bo Tang ORCID logo *ab  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China
E-mail: lina@sdnu.edu.cn, tangb@sdnu.edu.cn

b Laoshan Laboratory, Qingdao 266237, P. R. China

c Department of Health Management, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Engineering Laboratory for Health Management, Shandong Medicine and Health Key Laboratory of Laboratory Medicine, Jinan 250014, P. R. China

Abstract

By employing an aptamer as the bridge and combining catalytic hairpin assembly with the Au aggregation amplification effect, a lateral flow assay (LFA) is designed for simultaneous detection of liver cancer-associated miRNA and exosomes. The LFA can differentiate between liver cancer patients and healthy individuals with simple operation and high accuracy.

Graphical abstract: A lateral flow assay strip for simultaneous detection of miRNA and exosomes in liver cancer

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Article information

DOI
https://doi.org/10.1039/D4CC02559H
Article type
Communication
Submitted
27 May 2024
Accepted
24 Jun 2024
First published
24 Jun 2024

Chem. Commun., 2024,60, 7491-7494

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A lateral flow assay strip for simultaneous detection of miRNA and exosomes in liver cancer

R. Wei, D. Wang, P. Zhou, Y. Pan, X. Wan, W. Pan, N. Li and B. Tang, Chem. Commun., 2024, 60, 7491 DOI: 10.1039/D4CC02559H

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