Employing a PhI(OAc)2-mediated domino reaction to assemble nitrogen-containing heterocyclic derivatives and assessing their anti-inflammatory activity

Abstract

Metal-free radical cascade synthesis of substituted pyrazole derivatives was initiated by PhI(OAc)₂ at 23 °C. This protocol features wide functional group tolerance, a simple purification process without column chromatography, and an oxygen migration. Compound 5 demonstrated significant anti-inflammatory activity, indicating potential for therapy.