Thiophene assisted cellular uptake enhancement for highly efficient NIR-II cancer phototheranostics

Yue Zhang; Jia Yu; Chunbin Li; Jianye Gong; Yifan Wu; Lina Feng; Zihan Chen; Renmanduhu Sha; Guoyu Jiang; Jianguo Wang

doi:10.1039/D4CC03308F

Thiophene assisted cellular uptake enhancement for highly efficient NIR-II cancer phototheranostics†

Yue Zhang,

‡^a Jia Yu,‡^a Chunbin Li,^a Jianye Gong,^a Yifan Wu,^a Lina Feng,^a Zihan Chen,^a Renmanduhu Sha,^a Guoyu Jiang

*^a and Jianguo Wang

*^ab

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* Corresponding authors

^a College of Chemistry and Chemical Engineering, Inner Mongolia Key Laboratory of Fine Organic Synthesis, Inner Mongolia University, Hohhot 010021, P. R. China
E-mail: jiangguoyu@mail.ipc.ac.cn, wangjg@imu.edu.cn

^b Institutes of Biomedical Sciences, Inner Mongolia University, Hohhot 010021, P. R. China

Abstract

We designed two series of NIR-II PTAs with D–A or D–A–D structures, in which the introduction of thiophene promotes a bathochromic shift of emission into the NIR-II region, helps to improve the cellular uptake of the PTAs and facilitates NIR-II imaging-guided PDT/PTT cancer phototherapy.

This article is part of the themed collection: Chemical Communications HOT Articles 2024

Chemical Communications

Thiophene assisted cellular uptake enhancement for highly efficient NIR-II cancer phototheranostics†

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Thiophene assisted cellular uptake enhancement for highly efficient NIR-II cancer phototheranostics

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