Issue 89, 2024
From the journal:

Chemical Communications

Thioamide-based fluorescent sensors for dipeptidyl peptidase 4†

Hoang Anh T. Phan, ORCID logo a   Yanan Chang, ORCID logo a   Samuel A. Eaton ORCID logo a  and  E. James Petersson ORCID logo *ab  

* Corresponding authors

a Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, USA
E-mail: ejpetersson@sas.upenn.edu

b Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA

Abstract

Dipeptidyl peptidase 4 (DPP-4) is a promising biomarker for cancer and metabolic diseases. We demonstrate the design of novel fluorescent DPP-4 probes based on the protease's native substrates using a thioamide as a quencher for measuring in vitro kinetics, inhibition with sitagliptin, and DPP-4 activity in saliva samples.

Graphical abstract: Thioamide-based fluorescent sensors for dipeptidyl peptidase 4

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Article information

DOI
https://doi.org/10.1039/D4CC03309D
Article type
Communication
Submitted
03 Jul 2024
Accepted
08 Oct 2024
First published
23 Oct 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2024,60, 13075-13078

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Thioamide-based fluorescent sensors for dipeptidyl peptidase 4

H. A. T. Phan, Y. Chang, S. A. Eaton and E. J. Petersson, Chem. Commun., 2024, 60, 13075 DOI: 10.1039/D4CC03309D

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