Issue 76, 2024

Cobalt-catalyzed three-component assembly of aromatic oximes with substituted dienes and formaldehyde

Abstract

A cobalt-catalyzed three-component assembly of substituted aryl oximes with dienes and formaldehyde via C–H bond activation is described. This protocol affords highly regio- and chemoselective substituted homoallylic alcohols with moderate-to-excellent yields. The scope of this protocol has been extensively explored with various substituted aryl ketoximes and aldoximes. Butadiene and internally substituted dienes are also well compatible for this transformation. A plausible reaction mechanism is proposed to account for the present reaction and is supported by deuterium labeling studies.

Graphical abstract: Cobalt-catalyzed three-component assembly of aromatic oximes with substituted dienes and formaldehyde

Supplementary files

Article information

Article type
Communication
Submitted
31 Jul 2024
Accepted
20 Aug 2024
First published
27 Aug 2024

Chem. Commun., 2024,60, 10540-10543

Cobalt-catalyzed three-component assembly of aromatic oximes with substituted dienes and formaldehyde

P. Prusty and M. Jeganmohan, Chem. Commun., 2024, 60, 10540 DOI: 10.1039/D4CC03877K

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