Engineering biotin anchored-MWCNTs as a superb carrier for facile delivery of the potent Ru(II)-N^N scaffold in breast cancer cells

Lavanya Thilak Babu; Nilmadhab Roy; Tiasha Dasgupta; Sreejani Ghosh; Ramasamy Tamizhselvi; Priyankar Paira

doi:10.1039/D4CC04276J

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Engineering biotin anchored-MWCNTs as a superb carrier for facile delivery of the potent Ru(ii)-N^N scaffold in breast cancer cells†‡

Lavanya Thilak Babu,§^a Nilmadhab Roy,§^a Tiasha Dasgupta,^b Sreejani Ghosh,^a Ramasamy Tamizhselvi

^b and Priyankar Paira

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, School of Advanced Sciences (SAS), Vellore Institute of Technology (VIT), Vellore, Tamilnadu 632014, India
E-mail: priyankar.paira@vit.ac.in

^b Department of Bioscience, School of Bio-Sciences and Technology (SBST), Vellore Institute of Technology (VIT), Vellore, Tamilnadu 632014, India

Abstract

Ru(II)-complexes have been recognised as promising in treating cancer. However, targeted delivery is an important facet to augment the efficiency of drugs. Consequently, this article portrays the construction of biotinylated-MWCNTs as an SMVT-guided nano-platform for the precise delivery of our previously-developed potent Ru(II)-scaffold, making it more effective against MCF-7 cells.

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Article information

DOI: https://doi.org/10.1039/D4CC04276J
Article type: Communication
Submitted: 21 Aug 2024
Accepted: 03 Sep 2024
First published: 10 Sep 2024

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Chem. Commun., 2024,60, 13376-13379

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Engineering biotin anchored-MWCNTs as a superb carrier for facile delivery of the potent Ru(II)-N^N scaffold in breast cancer cells

L. T. Babu, N. Roy, T. Dasgupta, S. Ghosh, R. Tamizhselvi and P. Paira, Chem. Commun., 2024, 60, 13376 DOI: 10.1039/D4CC04276J

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Chemical Communications

Engineering biotin anchored-MWCNTs as a superb carrier for facile delivery of the potent Ru(ii)-N^N scaffold in breast cancer cells†‡

Abstract

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Engineering biotin anchored-MWCNTs as a superb carrier for facile delivery of the potent Ru(II)-N^N scaffold in breast cancer cells

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