Harnessing benzotriazole as a sustainable ligand in metal-catalyzed coupling reactions

Abstract

Coupling reactions play a crucial role in drug development enabling the rapid expansion of structure–activity relationships (SARs) during drug discovery programs to identify a clinical candidate and simplify subsequent drug development processes. In particular, their relevance in clinical medicine and drug discovery has increased significantly in the last two decades. To facilitate these metal-catalyzed coupling reactions, suitably designed ligands are necessary and from the industrial point of view, sustainable and cost-effective ligands are of current need. Benzotriazole, a non-toxic, thermally stable, and inexpensive bidentate ligand, exhibits strong electron donating and electron accepting properties, along with excellent solubility in various organic solvents. It has been extensively explored as a synthetic auxiliary in the past; in recent years, benzotriazole and its derivatives have been used as ligands in metal-catalyzed coupling reactions. The facile construction of carbon–carbon and carbon–heteroatom bonds in the presence of versatile benzotriazole ligands makes it an indispensable ligand for catalytic transformations. The present feature article mainly emphasizes the advances in the utilization of benzotriazole as a ligand in a diverse range of C–C, C–N, C–O, and C–S coupling reactions.