Reversible covalent electrophiles with the advantages of both reversible and covalent interactions receive much attention in the fields of chemical biology and medicinal chemistry. Here, we report two electron-deficient olefins activated by amide and ester, amide-substituted acrylamide and methyl ester-substituted acrylamide, targeting thiols in a reversible covalent manner.
X. Ma, M. Xu, F. Wang, T. Hu, X. Chen and C. Zhang, Chem. Commun., 2024, 60, 12437 DOI: 10.1039/D4CC04612A
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