We report a new streamlined approach for the difluoromethylation of ubiquitous phenols using inexpensive bromo(difluoro)acetic acid, yielding a wide array of structurally diverse OCF2H-based building blocks in a single step. This method displays broad functional group compatibility and is amenable for effective late-stage diversification and lignin-derived monomers.
S. Kumawat and K. Natte, Chem. Commun., 2024, 60, 13935 DOI: 10.1039/D4CC04782F
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