Issue 85, 2024
From the journal:

Chemical Communications

Electrochemically grafted gallic acid-chitosan: a metal-free in situ redox platform for regiospecific oligopeptide-viral spike protein interaction†

Vinoth Krishnan, ORCID logo ab   Chinnaiah Sivakumar,ab   Kannadasan Anand Babu, ORCID logo c   Sevakumaran Vigneswari,d   Rajamani Lakshminarayanan, ORCID logo e   Sudhakar Natarajan ORCID logo f  and  Murugan Veerapandian ORCID logo *ab  

* Corresponding authors

a Electrodics and Electrocatalysis Division, CSIR-Central Electrochemical Research Institute (CECRI), Karaikudi, Tamil Nadu, India

b Academy of Scientific & Innovative Research (AcSIR), Ghaziabad-201 002, India
E-mail: vmurugan@cecri.res.in

c Anderson Clinical Genetics, Anderson Diagnostics and Labs, Chennai, Tamil Nadu, India

d Institute of Climate Adaptation and Marine Biotechnology (ICAMB), Kuala Nerus 21030, Terengganu, Malaysia

e Ocular Infections and Antimicrobials Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, Singapore 169856, Singapore

f Department of Virology and Biotechnology, ICMR-National Institute for Research in Tuberculosis (NIRT), Chennai 600031, Tamil Nadu, India

Abstract

Electrochemical grafting of gallic acid with chitosan (EgGC) voltammetrically deposited on a multitude of substrates exhibiting reversible oxidoreduction suitable for sensor construction is reported. A bioreceptor customized from the fragment antigen binding region of SARS-CoV-2 neutralizing antibodies immobilized on an EgGC matrix supported the selective/specific electrochemical signal transduction with respect to different viral loads (femtogram level) of SARS-CoV-2.

Graphical abstract: Electrochemically grafted gallic acid-chitosan: a metal-free in situ redox platform for regiospecific oligopeptide-viral spike protein interaction

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Article information

DOI
https://doi.org/10.1039/D4CC04954C
Article type
Communication
Submitted
24 Sep 2024
Accepted
30 Sep 2024
First published
01 Oct 2024

Chem. Commun., 2024,60, 12405-12408

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Electrochemically grafted gallic acid-chitosan: a metal-free in situ redox platform for regiospecific oligopeptide-viral spike protein interaction

V. Krishnan, C. Sivakumar, K. A. Babu, S. Vigneswari, R. Lakshminarayanan, S. Natarajan and M. Veerapandian, Chem. Commun., 2024, 60, 12405 DOI: 10.1039/D4CC04954C

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