Issue 100, 2024
From the journal:

Chemical Communications

Acid-responsive liposomal nanodrug with promoted tumor penetration for photoacoustic imaging-guided sonodynamic therapy†

Xiangli Li, ORCID logo a   Wen-Jing Tang,a   Wei Wang,a   Shuzhen Yue, ORCID logo *a   Huiqin Yao*b  and  Jun-Jie Zhu ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China
E-mail: shuzhyue@163.com, jjzhu@nju.edu.cn

b Department of Medical Chemistry, College of Basic Medicine, Ningxia Medical University, Yinchuan 750004, China
E-mail: yaohq@nxmu.edu.cn

Abstract

Herein, an acid-responsive liposomal nanodrug was developed for photoacoustic (PA) imaging-guided oxygen (O2)-independent sonodynamic therapy (SDT). This liposomal nanodrug offers several advantages: (i) it facilitates O2-independent alkyl radical generation upon ultrasound irradiation, (ii) it exhibits acid-responsive charge reversion that enhances tumor penetration, and (iii) it enables activated PA imaging for therapeutic feedback.

Graphical abstract: Acid-responsive liposomal nanodrug with promoted tumor penetration for photoacoustic imaging-guided sonodynamic therapy

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Article information

DOI
https://doi.org/10.1039/D4CC05043F
Article type
Communication
Submitted
27 Sep 2024
Accepted
19 Nov 2024
First published
21 Nov 2024

Chem. Commun., 2024,60, 15023-15026

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Acid-responsive liposomal nanodrug with promoted tumor penetration for photoacoustic imaging-guided sonodynamic therapy

X. Li, W. Tang, W. Wang, S. Yue, H. Yao and J. Zhu, Chem. Commun., 2024, 60, 15023 DOI: 10.1039/D4CC05043F

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